.. /ourapplications /KADEX /dexketoprofen.shtml

Dexketoprofen trometamol has anti-inflammatory, analgesic, and antipyretic properties and has been used since 1973, it has particular properties that makes us think this drug is capable to delay age-related neurodegeneration pathologies.

It is known that, in general, NSAIDs significantly suppress the production of immune cells. As NSAIDs affect prostaglandins, they affect the production of most fast-growing cells. This includes immune cells.

They suppress the production of new immune cells but leave existing immune cells functional. Large doses slowly reduce the immune response as the immune cells are renewed at a much lower rate, causing a gradual reduction of the immune system at much slower and less noticeable than the immediate effect of corticosteroids.
Now the effect significantly increases with dosage, at a nearly exponential rate. Increasing the dose five times reduced cell counts to a few percent of normal levels (note that this was NOT accomplished through apoptosis, but rather by halting the proliferation of new immune cells).


Dexketoprofen trometamol is an NSAID with an oral availability of almost 90%, and it is all absorbed in the stomach in less than 20-25 minutes, which is extremely fast for an oral drug.

Most NSAIDs are not very lipophilic. That is not the case with dexketoprofen. It is hugely lipophilic and can be detected in the brain at the same time as other tissues. More importantly, it does accumulate in the brain. I.e., dexketoprofen is THE anti-inflammatory of the brain.

Inflammation in the brain is the starting point of many dementias. An over-reactive immune system is also not helping. In the early 90's, it started to become evident that an increase in usage of arthritis or usage of anti-inflammatory drugs appeared to be associated with a reduced prevalence of Alzheimer's Disease or other neurodegenerative diseases.

Sleep deprivation increases cyclooxygenase-2 expression in neurons, and we know that sleep deprivation causes a non-functional brain state. Mice treated with a different NSAID called Parecoxib throughout their lives show memory-enhancing effects.
In people who suffer from bipolar disorder, NSAIDs can be used as mood stabilizers. In mice models, inhibiting COX2 in the brain with NSAID reduces anxiety-like behavior and stops several steps in the progression of Alzheimer's disease. Some NSAIDs have been reported to inhibit amyloid beta-protein-induced neurotoxicity in culture and animal experiments. In the clinical trials, it has been revealed that long-term use of some NSAIDs indeed reduces the risk of Alzheimer's disease, as it has been suspected since the early 90s. Even in Parkinson's, several NSAIDs have protective effects against dopaminergic cell loss in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian models.


It is in my opinion that with high lipophilic, potent (2x potent ketoprofen), rapid absorption rate, and brain accumulation. Dexketoprofen trometamol, is a underated and powerful anti-neurodegenerative agent for the human brain that can be already deployed for prevention.

How to use it?
Best way to use this drug would be once a few weeks or when there was a stress in the brain recently, use of drugs like methamphetamines or stimulants. Sleep deprivation.
One box should last for 3-4 months.