It is known that, in general, NSAIDs significantly suppress the production of immune cells. As NSAIDs affect prostaglandins, they affect the production of most fast-growing cells. This includes immune cells. They suppress the production of new immune cells but leave existing immune cells functional. Large doses slowly reduce the immune response as the immune cells are renewed at a much lower rate, causing a gradual reduction of the immune system at much slower and less noticeable than the immediate effect of corticosteroids. Now the effect significantly increases with dosage, at a nearly exponential rate. Increasing the dose five times reduced cell counts to a few percent of normal levels (note that this was NOT accomplished through apoptosis, but rather by halting the proliferation of new immune cells). |
Sleep deprivation increases cyclooxygenase-2 expression in neurons, and we know that sleep deprivation causes a non-functional brain state. Mice treated with a different NSAID called Parecoxib throughout their lives show memory-enhancing effects. In people who suffer from bipolar disorder, NSAIDs can be used as mood stabilizers. In mice models, inhibiting COX2 in the brain with NSAID reduces anxiety-like behavior and stops several steps in the progression of Alzheimer's disease. Some NSAIDs have been reported to inhibit amyloid beta-protein-induced neurotoxicity in culture and animal experiments. In the clinical trials, it has been revealed that long-term use of some NSAIDs indeed reduces the risk of Alzheimer's disease, as it has been suspected since the early 90s. Even in Parkinson's, several NSAIDs have protective effects against dopaminergic cell loss in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian models. |
How to use it? Best way to use this drug would be once a few weeks or when there was a stress in the brain recently, use of drugs like methamphetamines or stimulants. Sleep deprivation. One box should last for 3-4 months. |