.. /ourapplications /BUSPIRONE

Buspirone is 10mg of the active substance N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,1-cyclopentanediacetamide

Buspirone hydrochloride is serotonin 5-HT1A receptor agonist, and antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.
First synthesized in 1968 then patented in 1975, it is commonly marketed under the brand name Buspar®.
Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.
The potential use of buspirone in combination with melatonin in depression and cognitive impairment via promoting neurogenesis has been investigated.
Buspirone acts as a full agonist at presynaptic 5-HT1A receptors, or 5-HT1A autoreceptors, expressed at dorsal raphe while acting as a partial agonist at the postsynaptic 5-HT1A receptors expressed on hippocampus and cortex.

Chemical Structure
Drug Class
Mechanisms of action
The therapeutic action of buspirone in generalized anxiety disorders is thought to be mainly derived from its interaction with 5-HT1A receptor subtypes that are involved in the brain's anxiety and fear circuitry to enhance the serotonergic activity in these brain areas.
10 mg

10mg @ 2€ UNITS 60

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